On Flexible, available regions depend on the underlying provider. Pick the provider and region pair according to audience latency and operational requirements, not brand preference alone.
Latency starts with geography
For dynamic requests, distance between visitor and origin still matters even when a CDN is present. Put the origin near the largest or most valuable audience when other constraints allow.
Provider choice changes region availability
DigitalOcean, AWS, Google Cloud, Vultr and Linode expose different region footprints through Cloudways. The best provider can therefore change when geography is a hard requirement.
Moving regions is an operational change
Changing provider or location can involve cloning, migration and DNS considerations. Treat the region as part of architecture rather than a cosmetic setting.
Decision takeaway
Choose the region before launch if latency or data-location requirements are important, and document how you would move if the audience changes.